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The endoplasmic reticulum stress response chaperone Gp96, a host receptor for Crohn disease-associated adherent-invasive<i>Escherichia coli</i>

28 Mar 2011

Abstract excerpt

Ileal lesions of Crohn disease (CD) patients are abnormally colonized by adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, endoplasmic stress was recently reported to have a key role in CD patients after the discovery, in CD patients, of several single nucleotide polymorphisms within gene encoding key component of the...

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PMID: 21637029
DOI: 10.4161/gmic.2.2.15725

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