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Article

Genetic and nongenetic mechanisms for colorectal cancer evolution.

Cancer science - 1 Sept 2023

Kok Sau Yee, Nakayama Mizuho, Morita Atsuya, Oshima Hiroko, Oshima Masanobu

Abstract excerpt

The stepwise accumulation of key driver mutations is responsible for the development and malignant progression of colorectal cancer in primary sites. Genetic mouse model studies have revealed combinations of driver gene mutations that induce phenotypic changes in tumors toward malignancy. However, cancer evolution is regulated by not only genetic alterations but also nongenetic mechanisms. For example, certain...

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PMID: 37357016
DOI: 10.1111/cas.15891
PMCID: PMC10475778

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