Article
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
Nature - 16 Oct 2008
Janoueix-Lerosey Isabelle, Lequin Delphine, Brugières Laurence, Ribeiro Agnès, de Pontual Loïc, Combaret Valérie, Raynal Virginie, Puisieux Alain, Schleiermacher Gudrun, Pierron Gaëlle, Valteau-Couanet Dominique, Frebourg Thierry, Michon Jean, Lyonnet Stanislas, Amiel Jeanne, Delattre Olivier
Abstract excerpt
Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of the most frequent solid tumours in childhood. It usually occurs sporadically but familial cases are observed, with a subset of cases occurring in association with congenital malformations of the neural crest being linked to germline mutations of the PHOX2B gene. Here we conducted genome-wide comparative genomic hybridization...
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