Article
Fas 670 promoter polymorphism is associated to susceptibility, clinical presentation, and survival in adult T cell leukemia.
Journal of leukocyte biology - 1 Jan 2008
Farre L, Bittencourt A L, Silva-Santos G, Almeida A, Silva A C, Decanine D, Soares G M, Alcantara L C, Van Dooren S, Galvão-Castro B, Vandamme A M, Van Weyenbergh J
Abstract excerpt
Fas (TNFRSF6/Apo-1/CD95) is a type I transmembrane receptor, which mediates apoptosis. Fas gene mutations, aberrant transcripts, and abundant expression of Fas have been reported in adult T cell leukemia (ATL). To further elucidate the role of Fas in ATL pathogenesis, we investigated whether the -670 FAS promoter A/G polymorphism (STAT1-binding site) might contribute to susceptibility and clinical outcome in ATL....
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