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Article

Functional FAS promoter polymorphisms are associated with increased risk of acute myeloid leukemia.

Cancer research - 1 Aug 2003

Sibley Kathryn, Rollinson Sara, Allan James M, Smith Alexandra G, Law Graham R, Roddam Philippa L, Skibola Christine F, Smith Martyn T, Morgan Gareth J

Abstract excerpt

The FAS (TNFRSF6/CD95/APO-1) gene is silenced in many tumor types, resulting in an inability to respond to proapoptotic signals. The FAS promoter is polymorphic, including a G to A substitution at -1377 bp and an A to G substitution at -670 bp, which occur within SP1 and signal transducers and activators of transcription 1 transcription factor binding sites, respectively. In a case-control study of adult acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fas Receptor

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Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 12907599

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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