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Article

Genetic variation in the immune system and malaria susceptibility in infants: a nested case-control study in Nanoro, Burkina Faso.

Malaria journal - 16 Feb 2021

Natama Hamatandi Magloire, Rovira-Vallbona Eduard, Krit Meryam, Guetens Pieter, Sorgho Hermann, Somé M Athanase, Traoré-Coulibaly Maminata, Valéa Innocent, Mens Petra F, Schallig Henk D F H, Berkvens Dirk, Kestens Luc, Tinto Halidou, Rosanas-Urgell Anna

Abstract excerpt

BACKGROUND: Genetic polymorphisms in the human immune system modulate susceptibility to malaria. However, there is a paucity of data on the contribution of immunogenetic variants to malaria susceptibility in infants, who present differential biological features related to the immaturity of their adaptive immune system, the protective effect of maternal antibodies and fetal haemoglobin. This study investigated the...

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Identifiers

PMID: 33593344
DOI: 10.1186/s12936-021-03628-y
PMCID: PMC7885350

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