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Article

FGFR-4 Arg³⁸⁸ enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2011

Yu Wendong, Feng Shu, Dakhova Olga, Creighton Chad J, Cai Yi, Wang Jianghua, Li Rile, Frolov Anna, Ayala Gustavo, Ittmann Michael

Abstract excerpt

PURPOSE: Increased expression of FGFR-4 and its ligands have been linked to lethal prostate cancer (PCa). Furthermore, a germ line polymorphism in the FGFR-4 gene, resulting in arginine at codon 388 (Arg³⁸⁸) instead of glycine (Gly³⁸⁸), is associated with aggressive disease. The FGFR-4 Arg³⁸⁸ variant results in increased receptor stability, sustained receptor activation, and increased motility and invasion...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21622724
DOI: 10.1158/1078-0432.CCR-10-2858
PMCID: PMC3131485

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SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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