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Article

Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2004

Horvath Lisa G, Henshall Susan M, Kench James G, Saunders Darren N, Lee C-Soon, Golovsky David, Brenner Phillip C, O'Neill Gordon F, Kooner Raji, Stricker Phillip D, Grygiel John J, Sutherland Robert L

Abstract excerpt

PURPOSE: Activation of the Wnt-signaling pathway is implicated in aberrant cellular proliferation in a variety of cancers. Secreted frizzled-related protein 4 (sFRP4) is a secreted protein with putative inhibitory activity of the Wnt-signaling cascade through binding and sequestering Wnt ligands. Because sFRP4 mRNA is overexpressed in prostate cancers (PCs), the aim of this study was to define the pattern of...

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PMID: 14760084
DOI: 10.1158/1078-0432.ccr-0707-03

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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