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Article

Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype.

The Journal of pathology - 1 Mar 2010

Murphy Tania, Darby Steve, Mathers Marie E, Gnanapragasam Vincent J

Abstract excerpt

Multiple fibroblast growth factor (FGF) axis alterations are known to occur in prostate cancer. Here we simultaneously profiled key components of this axis to determine their relevance in disease progression. An optimized immunohistochemistry protocol was used in expression analysis of FGF2, FGF8, FGFR1, FGFR4, and Sef (similar expression to FGF) in a single TMA of prostate cancer. FGF ligands and receptors were...

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Source

Identifiers

PMID: 19960500
DOI: 10.1002/path.2657

Genes

FGFR4
FGF2
FGF8
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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