Article
Oncogenic activation in prostate cancer progression and metastasis: Molecular insights and future challenges
1 Jan 2012
Abstract excerpt
Prostate cancer is a leading cause of death among men in the United States, and currently early diagnosis and appropriate treatment remain key approaches for patient care. Molecularly prostate cancer cells carry multiple perturbations that generate malignant phenotype capable of uncontrolled growth, survival, and invasion-metastasis to other organs. These alterations are acquired both by genetic and epigenetic...
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