Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype.

Leukemia research - 1 Jan 2012

Haferlach Torsten, Bacher Ulrike, Alpermann Tamara, Haferlach Claudia, Kern Wolfgang, Schnittger Susanne

Abstract excerpt

FLT3-ITDs are linked to higher leukocytes/blasts in acute myeloid leukemia. To evaluate the effect of NPM1 mutations, we correlated NPM1mut status with morphology in 805 adult normal karyotype AML. NPM1mut were found in 391/805 (48.6%), FLT3-ITD in 219/805 (27.2%). Frequencies of FLT3-ITD and NPM1mut cases were continuously increasing by blast decades: NPM1mut from 38/123 (30.9%) in 20-29% blast decade to 70/103...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Count

Share to fms-Like Tyrosine Kinase 3

Share to Gene Duplication

Share to Mutation Rate

Share to Nucleophosmin

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 21621842
DOI: 10.1016/j.leukres.2011.04.026

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amount of bone marrow blasts is strongly correlated to NPM1 and FLT3-ITD mutation rate in AML with normal karyotype.PMID 21621842Read ↗

[Correlation of NPM1, FLT3-ITD mutations with leukocyte count and myeloblasts percentage in AML patients with normal karyotype].Semantic proximity Read ↗

Mutation of NPM1 and FLT3 genes in acute myeloid leukemia and their association with clinical and immunophenotypic features.Semantic proximity Read ↗

NPM1-mutated myeloid neoplasms are a unique entity not defined by bone marrow blast percentage.Semantic proximity Read ↗

NPM1-Mutated Myeloid Neoplasms with <20% Blasts: A Really Distinct Clinico-Pathologic Entity?Semantic proximity Read ↗

[A study of NPM1 and FLT3 gene mutations in acute myeloid leukemia].Semantic proximity Read ↗

Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy.Semantic proximity Read ↗

Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia.Semantic proximity Read ↗

NPM1 and FLT3 mutations in acute myeloid leukemia with normal karyotype: Indian perspective.Semantic proximity Read ↗

"Cup-like" blasts and NPM1 and FLT3 (ITD) mutations in acute myeloid leukemia (AML).Semantic proximity Read ↗

NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).Semantic proximity Read ↗

Heterogeneous leukemic clones identified by NPM1 mutation analysis in patient with acute monocytic leukemia.Semantic proximity Read ↗

"Cup-like" blasts in acute myeloid leukemia with FLT3 and NPM1 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.