Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia.

doi:10.1016/j.clml.2012.01.003

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Article

Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia.

Clinical lymphoma, myeloma & leukemia - 1 Aug 2012

Dalal Bakul I, Mansoor Soudeh, Manna Mita, Pi Steven, Sauro Giovanna Di, Hogge Donna E

Abstract excerpt

UNLABELLED: In 83 patients with cytogenetically normal acute myeloid leukemia (CN-AML), those with NPM1 and wild-type FLT3 (FLT3-wt) mutation and their poor prognostic combination had distinctive flow cytometric findings: CN-AML with a mutation of NPM1 (NPMI-Mt) were CD34(-), CD14(-), and CD2pos and CD4; those with FLT3-internal tandem duplications (ITD) were CD56pos, those with NPM1-Mt and FLT3-wt were CD34(-)...

Topics

Adult
Antigens, CD
Cytogenetics
Female
Flow Cytometry
Humans
Immunophenotyping
Karyotyping
Leukemia, Myeloid, Acute
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Nucleophosmin

Prognosis

Retrospective Studies

Survival Analysis

Young Adult

Source

Open in PubMed

Identifiers

PMID: 22481022
DOI: 10.1016/j.clml.2012.01.003

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically normal acute myeloid leukemia.PMID 22481022Read ↗

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