Article
NPM1-Mutated Myeloid Neoplasms with <20% Blasts: A Really Distinct Clinico-Pathologic Entity?
International journal of molecular sciences - 26 Nov 2020
Forghieri Fabio, Nasillo Vincenzo, Paolini Ambra, Bettelli Francesca, Pioli Valeria, Giusti Davide, Gilioli Andrea, Colasante Corrado, Acquaviva Gloria, Riva Giovanni, Barozzi Patrizia, Maffei Rossana, Potenza Leonardo, Marasca Roberto, Fozza Claudio, Tagliafico Enrico, Trenti Tommaso, Comoli Patrizia, Longo Giuseppe, Luppi Mario
Abstract excerpt
Nucleophosmin (NPM1) gene mutations rarely occur in non-acute myeloid neoplasms (MNs) with <20% blasts. Among nearly 10,000 patients investigated so far, molecular analyses documented NPM1 mutations in around 2% of myelodysplastic syndrome (MDS) cases, mainly belonging to MDS with excess of blasts, and 3% of myelodysplastic/myeloproliferative neoplasm (MDS/MPN) cases, prevalently classified as chronic...
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