Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy.

doi:10.1182/blood-2012-06-431122

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Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy.

Blood - 4 Apr 2013

Pratcorona Marta, Brunet Salut, Nomdedéu Josep, Ribera Josep Maria, Tormo Mar, Duarte Rafael, Escoda Lourdes, Guàrdia Ramon, Queipo de Llano M Paz, Salamero Olga, Bargay Joan, Pedro Carmen, Martí Josep Maria, Torrebadell Montserrat, Díaz-Beyá Marina, Camós Mireia, Colomer Dolors, Hoyos Montserrat, Sierra Jorge, Esteve Jordi

Abstract excerpt

Risk associated to FLT3 internal tandem duplication (FLT3-ITD) in patients with acute myeloid leukemia (AML) may depend on mutational burden and its interaction with other mutations. We analyzed the effect of FLT3-ITD/FLT3 wild-type (FLT3wt) ratio depending on NPM1 mutation (NPM1mut) in 303 patients with intermediate-risk cytogenetics AML treated with intensive chemotherapy. Among NPM1mut patients, FLT3wt and low...

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Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy.

Abstract excerpt

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Favorable outcome of patients with acute myeloid leukemia harboring a low-allelic burden FLT3-ITD mutation and concomitant NPM1 mutation: relevance to post-remission therapy.

Abstract excerpt

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