NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).

doi:10.1182/blood-2008-09-172668

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Article

NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).

Blood - 21 May 2009

Schneider Friederike, Hoster Eva, Unterhalt Michael, Schneider Stephanie, Dufour Annika, Benthaus Tobias, Mellert Gudrun, Zellmeier Evelin, Bohlander Stefan K, Feuring-Buske Michaela, Buske Christian, Braess Jan, Fritsch Susanne, Heinecke Achim, Sauerland Maria C, Berdel Wolfgang E, Buechner Thomas, Woermann Bernhard J, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

Mutations in the NPM1 gene represent the most frequent genetic alterations in patients with acute myeloid leukemia (AML) and are associated with a favorable outcome. In 690 normal karyotype (NK) AML patients the complete remission rates (CRs) and the percentage of patients with adequate in vivo blast cell reduction 1 week after the end of the first induction cycle were significantly higher in NPM1(+) (75% and...

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Identifiers

PMID: 19279329
DOI: 10.1182/blood-2008-09-172668

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NPM1 but not FLT3-ITD mutations predict early blast cell clearance and CR rate in patients with normal karyotype AML (NK-AML) or high-risk myelodysplastic syndrome (MDS).PMID 19279329Read ↗

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