Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks.

doi:10.1016/j.ajhg.2020.08.025

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks.

American journal of human genetics - 5 Nov 2020

Fritsche Lars G, Patil Snehal, Beesley Lauren J, VandeHaar Peter, Salvatore Maxwell, Ma Ying, Peng Robert B, Taliun Daniel, Zhou Xiang, Mukherjee Bhramar

Abstract excerpt

To facilitate scientific collaboration on polygenic risk scores (PRSs) research, we created an extensive PRS online repository for 35 common cancer traits integrating freely available genome-wide association studies (GWASs) summary statistics from three sources: published GWASs, the NHGRI-EBI GWAS Catalog, and UK Biobank-based GWASs. Our framework condenses these summary statistics into PRSs using various...

Topics

Adult
Aged
Biological Specimen Banks
Female
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Genomics
Humans
Internet

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Male

Middle Aged

Multifactorial Inheritance

Neoplasms

Phenotype

Quantitative Trait, Heritable

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 32991828
DOI: 10.1016/j.ajhg.2020.08.025
PMCID: PMC7675001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks.PMID 32991828Read ↗

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.Semantic proximity Read ↗

PGS-Depot: a comprehensive resource for polygenic scores constructed by summary statistics based methods.Semantic proximity Read ↗

Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWebSemantic proximity Read ↗

Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2.Semantic proximity Read ↗

<i>PGSFusion</i> streamlines polygenic score construction and epidemiological applications in biobank-scale cohortsSemantic proximity Read ↗

The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores.Semantic proximity Read ↗

Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative.Semantic proximity Read ↗

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobankSemantic proximity Read ↗

Optimizing and benchmarking polygenic risk scores with GWAS summary statistics.Semantic proximity Read ↗

Optimizing and benchmarking polygenic risk scores with GWAS summary statisticsSemantic proximity Read ↗

PGSbuilder: An end-to-end platform for human genome association analysis and polygenic risk score predictionsSemantic proximity Read ↗

Significant sparse polygenic risk scores across 813 traits in UK Biobank.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.