Article
Variants in IL28B in liver recipients and donors correlate with response to peg-interferon and ribavirin therapy for recurrent hepatitis C.
Gastroenterology - 1 Nov 2010
Fukuhara Takasuke, Taketomi Akinobu, Motomura Takashi, Okano Shinji, Ninomiya Akinori, Abe Takayuki, Uchiyama Hideaki, Soejima Yuji, Shirabe Ken, Matsuura Yoshiharu, Maehara Yoshihiko
Abstract excerpt
BACKGROUND & AIMS: Patients with hepatitis C virus (HCV)-related liver disease frequently undergo orthotopic liver transplantation, but recurrent hepatitis C is still a major cause of morbidity. Patients are treated with peg-interferon and ribavirin (PEG-IFN/RBV), which has substantial side effects and is costly. We investigated genetic factors of host, liver donor, and virus that might predict sensitivity of...
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