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Article

Hepatitis C virus: How genetic variability affects pathobiology of disease.

Journal of gastroenterology and hepatology - 1 Jan 2011

Chayama Kazuaki, Hayes C Nelson

Abstract excerpt

As an RNA virus, hepatitis C virus (HCV) shows a characteristically high level of nucleotide diversity. Accumulation of nucleotide substitutions in the virus has resulted in diversification into quasispecies, subtypes and distinct genotypes. Pathobiological studies linking nucleotide and amino acid sequences with clinical findings have identified relationships between certain genotypes and characteristic...

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Identifiers

PMID: 21199518
DOI: 10.1111/j.1440-1746.2010.06550.x

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