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Article

Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice.

PloS one - 1 Jan 2016

Chen Ran, Kobewka Michelle, Addison William, Lachance Gerald, Tyrrell D Lorne

Abstract excerpt

BACKGROUND: Hepatitis C virus infection is a global health problem. New direct-acting antiviral agents have been recently approved. However, due to their high cost and some genotypes remaining difficult to treat, interferon-based therapy with pegylated interferon and ribavirin likely may remain a component of hepatitis C virus treatment for some patients. Unfortunately, pegylated interferon / ribavirin treatment...

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Identifiers

PMID: 26765841
DOI: 10.1371/journal.pone.0147007
PMCID: PMC4713165

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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