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Article

Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of the IL28B gene.

Gut - 1 Sept 2013

Watanabe Tsunamasa, Sugauchi Fuminaka, Tanaka Yasuhito, Matsuura Kentaro, Yatsuhashi Hiroshi, Murakami Shuko, Iijima Sayuki, Iio Etsuko, Sugiyama Masaya, Shimada Takashi, Kakuni Masakazu, Kohara Michinori, Mizokami Masashi

Abstract excerpt

OBJECTIVE: Recent studies have demonstrated that genetic polymorphisms near the IL28B gene are associated with the clinical outcome of pegylated interferon α (peg-IFN-α) plus ribavirin therapy for patients with chronic hepatitis C virus (HCV). However, it is unclear whether genetic variations near the IL28B gene influence hepatic interferon (IFN)-stimulated gene (ISG) induction or cellular immune responses, lead...

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Identifiers

PMID: 23135762
DOI: 10.1136/gutjnl-2012-302553
PMCID: PMC3756516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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