Article
Germline genetic variation and treatment response on CCG-1891.
Pediatric blood & cancer - 1 May 2012
Sepe Dana M, McWilliams Thomas, Chen Jinbo, Kershenbaum Aaron, Zhao Huaqing, La Mei, Devidas Meenakshi, Lange Beverly, Rebbeck Timothy R, Aplenc Richard
Abstract excerpt
BACKGROUND: Recent studies suggest that polymorphisms in genes encoding enzymes involved in drug detoxification and metabolism may influence disease outcome in pediatric acute lymphoblastic leukemia (ALL). We sought to extend current knowledge by using standard and novel statistical methodology to examine polymorphic variants of genes and relapse risk, toxicity, and drug dose delivery in standard risk ALL....
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