Article
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
JAMA - 28 Jan 2009
Yang Jun J, Cheng Cheng, Yang Wenjian, Pei Deqing, Cao Xueyuan, Fan Yiping, Pounds Stanley B, Neale Geoffrey, Treviño Lisa R, French Deborah, Campana Dario, Downing James R, Evans William E, Pui Ching-Hon, Devidas Meenakshi, Bowman W P, Camitta Bruce M, Willman Cheryl L, Davies Stella M, Borowitz Michael J, Carroll William L, Hunger Stephen P, Relling Mary V
Abstract excerpt
CONTEXT: Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive malignancy. Although cure rates exceed 80%, considerable unexplained interindividual variability exists in treatment response. OBJECTIVES: To assess the contribution of inherited genetic variation to therapy response and to identify germline single-nucleotide polymorphisms (SNPs) associated with risk of minimal residual...
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