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Article

A TLR6 polymorphism is associated with increased risk of Legionnaires' disease.

Genes and immunity - 1 Oct 2013

Misch E A, Verbon A, Prins J M, Skerrett S J, Hawn T R

Abstract excerpt

Legionella pneumophila (Lp), the etiologic agent of Legionnaires' disease (LD), is an important cause of community-acquired and nosocomial pneumonia. However, the host immune and genetic determinants of human susceptibility to Lp are poorly understood. Here we show that both TLR6 and TLR1 cooperate with TLR2 to recognize Lp in transfected HEK293 cells. We also perform a human genetic association study of 14...

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Identifiers

PMID: 23823019
DOI: 10.1038/gene.2013.34
PMCID: PMC3791179

Genes

TLR6
TLR1
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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