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Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer.

Cancer letters - 18 Jun 2009

Ulybina Yulia M, Kuligina Ekatherina Sh, Mitiushkina Nathalia V, Rozanov Maxim E, Ivantsov Alexandr O, Ponomariova Daria N, Togo Alexandr V, Levchenko Evgeny V, Shutkin Vladimir A, Brenister Sergiu I, Devilee Peter, Zhivotovsky Boris, Hirvonen Ari, Imyanitov Evgeny N

Abstract excerpt

Apoptosis plays a role in the elimination of DNA-damaged cells thus protecting the host from cancer development. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. We tested 19 coding apoptotic gene SNPs in 2-stage molecular epidemiological study. For the preliminary sorting of SNP candidates, we employed...

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Identifiers

PMID: 19203830
DOI: 10.1016/j.canlet.2009.01.012

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