Article
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
Carcinogenesis - 1 Mar 2006
Frank Bernd, Hemminki Kari, Wappenschmidt Barbara, Meindl Alfons, Klaes Rüdiger, Schmutzler Rita K, Bugert Peter, Untch Michael, Bartram Claus R, Burwinkel Barbara
Abstract excerpt
Dysregulation of apoptosis plays a crucial role in carcinogenesis. As part of death receptor- and mitochondrion-mediated apoptosis, the homologues caspases 10 and 8 may act as low-penetrance breast cancer (BC) susceptibility genes. In death receptor-mediated apoptosis, engagement of death receptors by their ligands involves the assembly of the death-inducing signalling complex (DISC). In mitochondrion-mediated...
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