Article
Mutational analysis of apoptotic genes in familial aggregation of hematological malignancies.
Bulletin du cancer - 1 Sept 2021
Hamadou Walid Sabri, Mani Rahma, Bouali Nouha, Besbes Sawsen, Bourdon Violaine, El Abed Rym, Ben Youssef Yosra, Mari Véronique, Gesta Paul, Dreyfus Hélène, Bonadona Valérie, Dugast Catherine, Zattara Hélène, Faivre Laurence, Noguchi Tetsuro, Khélif Abderrahim, Sobol Hagay, Soua Zohra
Abstract excerpt
INTRODUCTION: Apoptosis deregulation have been associated to tumorigenesis process and was highlighted as a prominent hallmark of cancer. Several mutations have been reported in several forms of Blood cancer. However, it has never been investigated in familial aggregations of hematological malignancies. METHODS: In this study, we performed a mutational analysis by sequencing the entire coding regions in four key...
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