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Article

Association of a common variant of the CASP8 gene with reduced risk of breast cancer.

Journal of the National Cancer Institute - 15 Dec 2004

MacPherson Gordon, Healey Catherine S, Teare M Dawn, Balasubramanian Sabapathy P, Reed Malcolm W R, Pharoah Paul D P, Ponder Bruce A J, Meuth Mark, Bhattacharyya Nitai P, Cox Angela

Abstract excerpt

Apoptosis, or programmed cell death, is perturbed in many cancers. We tested the hypothesis that coding polymorphisms of the death receptor 4 (DR4), caspase-8 (CASP8), and caspase-10 (CASP10) genes might act as low-penetrance breast cancer genes. Single-nucleotide polymorphisms (SNPs) of these ge...

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Source

Identifiers

PMID: 15601643
DOI: 10.1093/jnci/dji001

Genes

CASP8
CASP10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15601643-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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