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Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB <sup>R120G</sup> Cardiomyocytes

27 May 2011

Abstract excerpt

RATIONALE: Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. Several cardiomyopathies, including the αB-crystallin R120G mutation (CryAB(R120G)) model of desmin-related cardiomyopathy, accumulate cytotoxic misfolded proteins in the form of preamyloid oligomers and aggresomes. Impaired autophagic function is a potential cause of...

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PMID: 21617129
DOI: 10.1161/circresaha.110.237339

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