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Article

Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.

Journal of the American Heart Association - 8 Aug 2017

Xu Na, Bitan Gal, Schrader Thomas, Klärner Frank-Gerrit, Osinska Hanna, Robbins Jeffrey

Abstract excerpt

BACKGROUND: Compromised protein quality control causes the accumulation of misfolded proteins and intracellular aggregates, contributing to cardiac disease and heart failure. The development of therapeutics directed at proteotoxicity-based pathology in heart disease is just beginning. The molecular tweezer CLR01 is a broad-spectrum inhibitor of abnormal self-assembly of amyloidogenic proteins, including amyloid...

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Identifiers

PMID: 28862927
DOI: 10.1161/JAHA.117.006182
PMCID: PMC5586456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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