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Article

Manipulation of death pathways in desmin-related cardiomyopathy.

Circulation research - 14 May 2010

Maloyan Alina, Sayegh Jennifer, Osinska Hanna, Chua Balvin H L, Robbins Jeffrey

Abstract excerpt

RATIONALE: Transgenic mice with cardiac specific overexpression of mutated alphaB-crystallin (CryAB(R120G)) display Desmin-related myopathy (DRM) with dilated cardiomyopathy and heart failure. Our previous studies showed the presence of progressive mitochondrial abnormalities and activation of apoptotic cell death in CryAB(R120G) transgenic hearts. However, the role of mitochondrial dysfunction and apoptosis in...

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3T3 Cells
alpha-Crystallin B Chain
Cardiomyopathy, Hypertrophic
Desmin
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-bcl-2

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Identifiers

PMID: 20360253
DOI: 10.1161/CIRCRESAHA.109.212639
PMCID: PMC2890082

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Manipulation of death pathways in desmin-related cardiomyopathy.PMID 20360253Read ↗

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