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Article

AlphaB-crystallin modulates protein aggregation of abnormal desmin.

Circulation research - 14 Nov 2003

Wang Xuejun, Klevitsky Raisa, Huang Wei, Glasford Joseph, Li Faqian, Robbins Jeffrey

Abstract excerpt

AlphaB-crystallin (CryAB) is the most abundant small heat shock protein in the heart. Upregulation of CryAB in desmin-related myopathy and its downregulation in end-stage congestive heart failure have both been reported. We previously demonstrated via cardiac-specific transgenesis that modest increases in normal CryAB are not detrimental to the heart, whereas expression of the R120G mutation of CryAB caused a...

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Identifiers

PMID: 14576194
DOI: 10.1161/01.RES.0000102401.77712.ED

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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