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Article

ATF4 overexpression induces early onset of hyperlipidaemia and hepatic steatosis and enhances adipogenesis in zebrafish.

Scientific reports - 27 Nov 2017

Yeh Kun-Yun, Lai Chi-Yu, Lin Chiu-Ya, Hsu Chia-Chun, Lo Chung-Ping, Her Guor Mour

Abstract excerpt

Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver diseases (NAFLD) and obesity. However, the role of ATF4 in animal model systems is poorly understood. To investigate ATF4 functions in zebrafish, we conditionally expressed ATF4 proteins, using a Tet-off...

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Source

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Identifiers

PMID: 29180630
DOI: 10.1038/s41598-017-16587-9
PMCID: PMC5703967

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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