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Article

Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2011

Mohammed Javid P, Fusakio Michael E, Rainbow Daniel B, Moule Carolyn, Fraser Heather I, Clark Jan, Todd John A, Peterson Laurence B, Savage Paul B, Wills-Karp Marsha, Ridgway William M, Wicker Linda S, Mattner Jochen

Abstract excerpt

Environmental and genetic factors define the susceptibility of an individual to autoimmune disease. Although common genetic pathways affect general immunological tolerance mechanisms in autoimmunity, the effects of such genes could vary under distinct immune challenges within different tissues. In this study, we demonstrate this by observing that autoimmune type 1 diabetes-protective haplotypes at the...

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Antigens, CD
Gram-Negative Bacterial Infections
Hepatitis, Autoimmune
Liver Cirrhosis, Biliary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred NOD

Mice, Transgenic

Severity of Illness Index

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Identifiers

PMID: 21613619
DOI: 10.4049/jimmunol.1003525
PMCID: PMC3134939

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