Article
Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization.
Clinical and experimental immunology - 1 Mar 2009
Wakabayashi K, Yoshida K, Leung P S C, Moritoki Y, Yang G-X, Tsuneyama K, Lian Z-X, Hibi T, Ansari A A, Wicker L S, Ridgway W M, Coppel R L, Mackay I R, Gershwin M E
Abstract excerpt
Our laboratory has suggested that loss of tolerance to pyruvate dehydrogenase (PDC-E2) leads to an anti-mitochondrial antibody response and autoimmune cholangitis, similar to human primary biliary cirrhosis (PBC). We have suggested that this loss of tolerance can be induced either via chemical xenobiotic immunization or exposure to select bacteria. Our work has also highlighted the importance of genetic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.