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Novosphingobium Aromaticivorans: A Potential Initiator of Primary Biliary Cirrhosis

1 Nov 2004

Abstract excerpt

Primary biliary cirrhosis (PBC) is characterized by a T-cell-mediated destruction of bile duct epithelial cells that line the small intrahepatic bile ducts. The targets of activated T-lymphocytes are the dihydrolipoamide acetyltransferase components of the 2 oxo acid dehydrogenases, enzyme complexes that are important in oxidative energy metabolism. Pyruvate dehydrogenase is the best known of these. Its...

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PMID: 15554995
DOI: 10.1111/j.1572-0241.2004.41121.x

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