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Article

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2011

Rainbow Daniel B, Moule Carolyn, Fraser Heather I, Clark Jan, Howlett Sarah K, Burren Oliver, Christensen Mikkel, Moody Val, Steward Charles A, Mohammed Javid P, Fusakio Michael E, Masteller Emma L, Finger Erik B, Houchins J P, Naf Dieter, Koentgen Frank, Ridgway William M, Todd John A, Bluestone Jeffrey A, Peterson Laurence B, Mattner Jochen, Wicker Linda S

Abstract excerpt

We have previously proposed that sequence variation of the CD101 gene between NOD and C57BL/6 mice accounts for the protection from type 1 diabetes (T1D) provided by the insulin-dependent diabetes susceptibility region 10 (Idd10), a <1 Mb region on mouse chromosome 3. In this study, we provide further support for the hypothesis that Cd101 is Idd10 using haplotype and expression analyses of novel Idd10 congenic...

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Antigens, CD
Autoimmune Diseases
CHO Cells
Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Diabetes Mellitus, Type 1

Mice, Inbred NOD

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Identifiers

PMID: 21613616
DOI: 10.4049/jimmunol.1003523
PMCID: PMC3128927

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Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.PMID 21613616Read ↗

Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.Semantic proximity Read ↗

Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice.Semantic proximity Read ↗

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.Semantic proximity Read ↗

Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.Semantic proximity Read ↗

The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.Semantic proximity Read ↗

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.Semantic proximity Read ↗

Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity.Semantic proximity Read ↗

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.Semantic proximity Read ↗

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

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