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Article

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1997

Podolin P L, Denny P, Lord C J, Hill N J, Todd J A, Peterson L B, Wicker L S, Lyons P A

Abstract excerpt

The development of autoimmune diabetes in the nonobese diabetic (NOD) mouse is under the control of multiple insulin-dependent diabetes (Idd) genes. The Idd3 gene, originally defined as a broad peak of linkage on mouse chromosome 3, was subsequently identified as two genes, Idd3 and Idd10, separated by at least 20 cM. The resistance alleles of Idd3 and Idd10 individually confer only partial protection from...

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PMID: 9257847

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Research trail→

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Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.PMID 9257847Read ↗

Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3.Semantic proximity Read ↗

Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.Semantic proximity Read ↗

Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice.Semantic proximity Read ↗

Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.Semantic proximity Read ↗

Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.Semantic proximity Read ↗

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.Semantic proximity Read ↗

Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.Semantic proximity Read ↗

Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.Semantic proximity Read ↗

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.Semantic proximity Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

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