Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence.

doi:10.1016/0042-6822(90)90029-q

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Article

Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence.

Virology - 1 Jun 1990

Lobigs M, Usha R, Nestorowicz A, Marshall I D, Weir R C, Dalgarno L

Abstract excerpt

We have passaged the prototype strain of Murray Valley encephalitis virus in SW13 (human) cells, sequenced the E and M genes, and examined the virulence of the passaged virus for 21-day-old mice following intracranial and intraperitoneal inoculation. Six independent passage series were carried out: four in the presence of mouse hyperimmune ascitic fluid and two without antibody. Changes were observed in the E...

Topics

Adenocarcinoma
Aedes
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Chick Embryo
Fibroblasts
Flavivirus
Genetic Variation
Humans
Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

RNA, Viral

Serial Passage

Togaviridae Infections

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2161151
DOI: 10.1016/0042-6822(90)90029-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2161151-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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