Article
Change in phenotype of tick-borne encephalitis virus following passage in Ixodes ricinus ticks and associated amino acid substitution in the envelope protein.
Virus research - 1 Mar 1994
Labuda M, Jiang W R, Kaluzova M, Kozuch O, Nuttall P A, Weismann P, Elĕckova E, Zuffová E, Gould E A
Abstract excerpt
Serial passage of an uncloned tick-borne encephalitis virus (strain 4387 isolated from the liver and lungs of a bank vole) in Ixodes ricinus ticks, was accompanied by gradual reduction in virulence of the virus, as indicated by transmission of virus by infected ticks feeding on laboratory mice. After the 7th serial passage in ticks (strain 4387/7), 95% of mice survived the bite of infected ticks. The surviving...
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