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Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage.

Virus genes - 1 Oct 2002

Fujii Yutaka, Sakaguchi Takemasa, Kiyotani Katsuhiro, Huang Chen, Fukuhara Noriko, Yoshida Tetsuya

Abstract excerpt

Abstract. We have reported that attenuation of the virulence of a field Sendai virus (SeV) isolated by egg passage is associated with an impediment of viral genome replication in mouse respiratory cells (Kiyotani et al., Arch Virol 146, 893-908, 2001). To determine the molecular basis for the attenuation, we sequenced entire genomes of representative SeV clones isolated during egg passages and compared those with...

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Identifiers

PMID: 12416681
DOI: 10.1023/a:1020165919672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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