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Article

A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.

Journal of virology - 1 Oct 1990

Holzmann H, Heinz F X, Mandl C W, Guirakhoo F, Kunz C

Abstract excerpt

We have determined the virulence characteristics of seven monoclonal antibody escape mutants of tick-borne encephalitis virus in the mouse model. One of the mutants with an amino acid substitution from tyrosine to histidine at residue 384 revealed strongly reduced pathogenicity after peripheral inoculation of adult mice but retained its capacity to replicate in the mice and to induce a high-titered antibody...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibody Formation
Chick Embryo
Disease Models, Animal
Encephalitis Viruses, Tick-Borne
Encephalitis, Tick-Borne
Mice
Models, Molecular
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Conformation

Vaccines, Attenuated

Viral Envelope Proteins

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2398538
DOI: 10.1128/JVI.64.10.5156-5159.1990
PMCID: PMC248008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2398538-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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