Article
A single nucleotide change in the E protein gene of dengue virus 2 Mexican strain affects neurovirulence in mice.
The Journal of general virology - 1 Oct 1996
Sánchez I J, Ruiz B H
Abstract excerpt
Eleven clones of dengue virus 2 Mexican strain were selected by the size of their lytic plaques. Nucleotide sequences of the clones producing large plaques (D2ML2, D2ML3 and D2ML4) revealed 11 mutations, 10 of which were silent. The substitution at nucleotide 1168 (G-->C) generates one amino acid...
Topics
- Amino Acid Sequence
- Animals
- Aspartic Acid
- Base Sequence
- Cell Line
- DNA, Viral
- Dengue Virus
- Genetic Variation
- Histidine
- Macaca mulatta
- Mexico
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Point Mutation
- RNA, Viral
- Sequence Homology, Amino Acid
- Viral Envelope Proteins