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Article

A single nucleotide change in the E protein gene of dengue virus 2 Mexican strain affects neurovirulence in mice.

The Journal of general virology - 1 Oct 1996

Sánchez I J, Ruiz B H

Abstract excerpt

Eleven clones of dengue virus 2 Mexican strain were selected by the size of their lytic plaques. Nucleotide sequences of the clones producing large plaques (D2ML2, D2ML3 and D2ML4) revealed 11 mutations, 10 of which were silent. The substitution at nucleotide 1168 (G-->C) generates one amino acid difference at residue 390 (Asp-->His) of the envelope protein (E). These clones showed high virulence in suckling mice...

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PMID: 8887488
DOI: 10.1099/0022-1317-77-10-2541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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