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Article

Identification of genetic determinants of a tick-borne flavivirus associated with host-specific adaptation and pathogenicity.

Virology - 25 Nov 2008

Mitzel Dana N, Best Sonja M, Masnick Max F, Porcella Stephen F, Wolfinbarger James B, Bloom Marshall E

Abstract excerpt

Tick-borne flaviviruses are maintained in nature in an enzootic cycle involving a tick vector and a vertebrate host. Thus, the virus replicates in two disparate hosts, each providing selective pressures that can influence virus replication and pathogenicity. To identify viral determinants associated with replication in the individual hosts, plaque purified Langat virus (TP21pp) was adapted to growth in mouse or...

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Source

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Identifiers

PMID: 18823640
DOI: 10.1016/j.virol.2008.08.030
PMCID: PMC2592254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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