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Article

Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein.

Journal of virology - 1 Aug 2001

Hurrelbrink R J, McMinn P C

Abstract excerpt

Molecular determinants of virulence in flaviviruses cluster in two regions on the three-dimensional structure of the envelope (E) protein; the base of domain II, believed to serve as a hinge during pH-dependent conformational change in the endosome, and the lateral face of domain III, which contains an integrin-binding motif Arg-Gly-Asp (RGD) in mosquito-borne flaviviruses and is believed to form the...

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Identifiers

PMID: 11462041
DOI: 10.1128/JVI.75.16.7692-7702.2001
PMCID: PMC115004

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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