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Article

Rapamycin Suppresses Tumor Growth and Alters the Metabolic Phenotype in T-Cell Lymphoma.

The Journal of investigative dermatology - 1 Sept 2015

Kittipongdaja Wasakorn, Wu Xuesong, Garner Justine, Liu Xiping, Komas Steven M, Hwang Sam T, Schieke Stefan M

Abstract excerpt

The mTOR pathway is a master regulator of cellular growth and metabolism. The biosynthetic and energetic demand of rapidly proliferating cells such as cancer cells is met by metabolic adaptations such as an increased glycolytic rate known as the Warburg effect. Herein, we characterize the anti-tumor effect of rapamycin in a mouse model of T-cell lymphoma and examine the metabolic effects in vitro. The murine...

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Identifiers

PMID: 25897830
DOI: 10.1038/jid.2015.153

Genes

MBL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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