Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC).

doi:10.1158/1078-0432.CCR-17-3416

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Article

Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC).

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2018

Frank Rieke, Scheffler Matthias, Merkelbach-Bruse Sabine, Ihle Michaela A, Kron Anna, Rauer Michael, Ueckeroth Frank, König Katharina, Michels Sebastian, Fischer Rieke, Eisert Anna, Fassunke Jana, Heydt Carina, Serke Monika, Ko Yon-Dschun, Gerigk Ulrich, Geist Thomas, Kaminsky Britta, Heukamp Lukas C, Clement-Ziza Mathieu, Büttner Reinhard, Wolf Jürgen

Abstract excerpt

Purpose:KEAP1 and NFE2L2 mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non-small cell lung cancer (NSCLC). However, little is known about frequency, histology dependence, molecular and clinical presentation as well as response to systemic treatment in NSCLC.Experimental Design: Tumor tissue of 1,391 patients with NSCLC was analyzed using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29615460
DOI: 10.1158/1078-0432.CCR-17-3416

Genes

KEAP1
EGFR
MET

Provenance

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