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Article

The 894G > T (Glu298Asp) variant in the endothelial NOS gene and MTHFR polymorphisms influence homocysteine levels in patients with cognitive decline.

Neuromolecular medicine - 1 Sept 2011

Ferlazzo Nadia, Gorgone Gaetano, Caccamo Daniela, Currò Monica, Condello Salvatore, Pisani Francesco, Vernieri Fabrizio, Rossini Paolo Maria, Ientile Riccardo

Abstract excerpt

The presence and severity of cerebrovascular pathological findings have been shown to increase the risk and stage of cognitive decline observed in Alzheimer's disease and vascular dementia. Thus, the modification of vascular risk factors seems useful to reduce the risk of dementia regardless of type. Hyperhomocysteinemia has long been known as a major independent risk factor for vascular dysfunction. In this...

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Source

Identifiers

PMID: 21607713
DOI: 10.1007/s12017-011-8148-8

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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