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Article

The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

24 Oct 2022

Abstract excerpt

The prevalence and severity of hypertension-induced cognitive impairment increase with the prolonging of hypertension. The mechanisms of cognitive impairment induced by hypertension primarily include cerebral blood flow perfusion imbalance, white and gray matter injury with blood–brain barrier disruption, neuroinflammation and amyloid-beta deposition, genetic polymorphisms and variants, and instability of blood...

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PMID: 36352848
DOI: 10.3389/fcvm.2022.928701

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