Article
Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women.
Atherosclerosis - 1 Jul 2001
Passaro A, Vanini A, Calzoni F, Alberti L, Zamboni P F, Fellin R, Solini A
Abstract excerpt
Plasma homocysteine (Hcy) is an independent vascular risk factor. Its remethylation to methionine is regulated by the activity of the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR). A C-to-T substitution at nucleotide 677 of the MTHFR gene is frequently associated to hyperhomocysteinemia. In this study, we evaluated the relationship among MTHFR C677T polymorphism, Hcy and some ultrasonographic...
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