Article
Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Alexopoulos Panagiotis, Richter-Schmidinger Tanja, Horn Marco, Maus Sebastian, Reichel Martin, Sidiropoulos Christos, Rhein Cosima, Lewczuk Piotr, Doerfler Arnd, Kornhuber Johannes
Abstract excerpt
The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for the development of late-onset Alzheimer's disease (AD), whereas the presence of the APOE ε2 allele seems to confer protection. Here, we report that healthy young APOE ε4 carriers have statistically significantly smaller hippocampal volumes than APOE ε2 carriers, while no differences were detected between the two groups in memory...
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